2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-108682R
    EMPA (Standard) 680590-49-2
    EMPA (Standard) is the analytical standard of EMPA (HY-108682). This product is intended for research and analytical applications. EMPA is a high-affinity, reversible and selective orexin OX2 receptor antagonist. [3H]EMPA binds to human and rat OX2-HEK293 membranes with Kd values of 1.1 and 1.4 nM respectively.
    EMPA (Standard)
  • HY-108698R
    Preclamol hydrochloride (Standard) 88768-67-6
    Preclamol hydrochloride (Standard) is the analytical standard of Preclamol (hydrochloride) (HY-108698). This product is intended for research and analytical applications. Preclamol hydrochloride ((-)-3-PPP hydrochloride) is a selective dopamine autoreceptor agonist. Preclamol hydrochloride has the potential for the research of schizophrenia.
    Preclamol hydrochloride (Standard)
  • HY-108699R
    TM-N1324 (Standard) 1144477-35-9
    TM-N1324 (Standard) is the analytical standard of TM-N1324 (HY-108699). This product is intended for research and analytical applications. TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9 nM/5 nM in the presence of Zn2+, and 280 nM/180 nM in the absence of Zn2+ for human/murine GPR39.
    TM-N1324 (Standard)
  • HY-108707R
    LY3130481 (Standard) 1610802-47-5
    LY3130481 (Standard) is the analytical standard of LY3130481 (HY-108707). This product is intended for research and analytical applications. LY3130481 is an orally available AMPA receptor antagonist, selectively inhibiting the IC50 value of AMPA/TARP γ-8 at 65 nM. LY3130481 has anticonvulsant, antiepileptic, and pain-relieving effects.
    LY3130481 (Standard)
  • HY-108710R
    VU0650786 (Standard) 1809085-30-0
    VU0650786 (Standard) is the analytical standard of VU0650786 (HY-108710). This product is intended for research and analytical applications. VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents.
    VU0650786 (Standard)
  • HY-108715R
    Real Thiol (Standard) 2280796-90-7
    Real Thiol (Standard) is the analytical standard of Real Thiol (HY-108715). This product is intended for research and analytical applications. Real Thiol is a reversible reaction-based fluorescent probe which can quantitatively monitor the real-time glutathione dynamics in living cells.
    Real Thiol (Standard)
  • HY-108751R
    Aripiprazole Lauroxil (Standard) 1259305-29-7 98%
    Aripiprazole Lauroxil (Standard) is the analytical standard of Aripiprazole Lauroxil. This product is intended for research and analytical applications. Aripiprazole lauroxil, an N-acyloxymethyl proagent of Aripiprazole (HY-14546), is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia and a ligand of dopamine receptor D2R/D4R. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity.
    Aripiprazole Lauroxil (Standard)
  • HY-108937R
    NSC 15364 (Standard) 4550-72-5
    NSC 15364 (Standard) is the analytical standard of NSC 15364 (HY-108937). This product is intended for research and analytical applications. NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis.
    NSC 15364 (Standard)
  • HY-108974R
    Drotaverine hydrochloride (Standard) 985-12-6 98%
    Drotaverine (hydrochloride) (Standard) is the analytical standard of Drotaverine (hydrochloride). This product is intended for research and analytical applications. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects.
    Drotaverine hydrochloride (Standard)
  • HY-109001R
    Alicapistat (Standard) 1254698-46-8
    Alicapistat (Standard) is the analytical standard of Alicapistat (HY-109001). This product is intended for research and analytical applications. Alicapistat (ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD). Alicapistat mitigates the metabolic liability of carbonyl reduction and inhibits calpain 1 with an IC50 value of 395 nM.
    Alicapistat (Standard)
  • HY-109009R
    Padsevonil (Standard) 1294000-61-5
    Padsevonil (Standard) is the analytical standard of Padsevonil (HY-109009). This product is intended for research and analytical applications. Padsevonil (UCB0942) is a potent antiepileptic agent that selectively acts on presynaptic and postsynaptic targets. Padsevonil binds to synaptic vesicular protein 2 (SV2) with high affinity. Padsevonil is also a positive allosteric modulator and partial agonist of GABAAR, with high potency against α1 and α5 receptors. Padsevonil has antiepileptic effects in a variety of rodent models.
    Padsevonil (Standard)
  • HY-109012R
    Seltorexant (Standard) 1293281-49-8
    Seltorexant (Standard) is the analytical standard of Seltorexant (HY-109012). This product is intended for research and analytical applications. Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.
    Seltorexant (Standard)
  • HY-109013R
    Sofpironium bromide (Standard) 1628106-94-4
    Sofpironium bromide (Standard) is the analytical standard of Sofpironium (bromide) (HY-109013). This product is intended for research and analytical applications. Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes.
    Sofpironium bromide (Standard)
  • HY-109022R
    Atogepant (Standard) 1374248-81-3
    Atogepant (Standard) is the analytical standard of Atogepant (HY-109022). This product is intended for research and analytical applications. Atogepant (MK-8031) is an orally active and selective calcitonin gene-related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine.
    Atogepant (Standard)
  • HY-109024R
    Balovaptan (Standard) 1228088-30-9
    Balovaptan (Standard) is the analytical standard of Balovaptan (HY-109024). This product is intended for research and analytical applications. Balovaptan (RG7314) is an orally available, selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.
    Balovaptan (Standard)
  • HY-109040R
    Quilseconazole (Standard) 1340593-70-5 98%
    Quilseconazole (Standard) is the analytical standard of Quilseconazole (HY-109040). This product is intended for research and analytical applications. Quilseconazole (VT-1129) is an orally active, highly selective fungal cytochrome P450 enzyme Cyp51 inhibitor that can cross the blood-brain barrier. Quilseconazole prevents the synthesis of ergosterol, an important component of the fungal cell membrane, by inhibiting Cyp51. Quilseconazole has minimal effects on human CYP enzymes. Quilseconazole has antifungal activity and can be used in the study of cryptococcal meningitis and other diseases.
    Quilseconazole (Standard)
  • HY-109046R
    Tulrampator (Standard) 1038984-31-4
    Tulrampator (Standard) is the analytical standard of Tulrampator (HY-109046). This product is intended for research and analytical applications. Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder.
    Tulrampator (Standard)
  • HY-109055R
    Elenbecestat (Standard) 1388651-30-6
    Elenbecestat (Standard) is the analytical standard of Elenbecestat (HY-109055). This product is intended for research and analytical applications. Elenbecestat (E2609) is a potent, orally bioavailable and BBB-penetrant BACE-1 inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research.
    Elenbecestat (Standard)
  • HY-109061R
    Lazertinib (Standard) 1903008-80-9
    Lazertinib (Standard) is the analytical standard of Lazertinib (HY-109061). This product is intended for research and analytical applications. Lazertinib (YH25448) is a potent, selective, CNS-penetrant, orally available and irreversible EGFR tyrosine Kinase inhibitor, exhibiting high selectivity for activating (EGFRm) and T790M resistance mutations. Lazertinib inhibits phosphorylation of EGFR, AKT and ERK, leading to apoptosis and suppression of tumor growth in mouse H1975-luc brain metastasis xenograft models. Lazertinib can be used in the study of non-small cell lung cancer.
    Lazertinib (Standard)
  • HY-109101R
    Risdiplam (Standard) 1825352-65-5 98%
    Risdiplam (Standard) is the analytical standard of Risdiplam. This product is intended for research and analytical applications. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.
    Risdiplam (Standard)
Cat. No. Product Name / Synonyms Application Reactivity